Metabolism of angiotensin II-I-131 in normotensive and hypertensive human subjects.

B IOLOGICAL ASSAYS of angiotensin in the blood of patients with normal blood pressures, patients with benign essential hypertension, and patients with malignant hypertension indicate that there are significantly greater quantities of angiotensin in the subjects with benign essential hypertension than in the normotensive group and that the greatest quantities of angiotensin are present in the patients with malignant hypertension. The present investigations were designed to determine the metabolism and rate of turnover of angiotensin in normotensive and hypertensive human subjects.